BDBM50065304 3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL313578

SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=PLAOAGFXNCEZMZ-LCYFTJDESA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50065304   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50:  230nMAssay Description:Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50:  2.70E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Affinity DataIC50:  8.39E+3nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed