BDBM50111443 2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540)::CHEMBL440470

SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O

InChI Key InChIKey=SURCGQGDUADKBL-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50111443   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  5.88E+3nMAssay Description:Inhibition of NGF-stimulated Trk AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  3.72E+3nMAssay Description:Inhibition of NGF-stimulated Trk AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 16(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  3.72E+3nMAssay Description:Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  1.49E+5nMAssay Description:Inhibition of mouse NGF binding to TrkA (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 16(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of mouse NGF binding to p75 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataIC50:  5.88E+3nMAssay Description:Inhibition of binding of [125I]-NGF to TrkA in rat PC12 cells incubated for 2 hrs by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50111443(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Affinity DataEC50:  2.20E+4nMAssay Description:Inhibition of NGF-induced TrkA auto-phosphorylation in rat PC12 cells incubated for 15 mins by chemiluminescence based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed