BDBM50127222 CHEMBL38508::GW-0742::{4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid

SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=HWVNEWGKWRGSRK-UHFFFAOYSA-N

Data  3 IC50  1 Kd  23 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50127222   

TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  1nMAssay Description:Maximum transcriptional activation of human PPAR delta receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human PPARdelta measured by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  30nMAssay Description:Activity against murine PPAR delta receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  1.10E+3nMAssay Description:Maximum transcriptional activation of human PPAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  8.80E+3nMAssay Description:Activity against murine PPAR alpha receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity against murine PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  2.00E+3nMAssay Description:Maximum transcriptional activation of human PPAR gamma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  67nMAssay Description:Activation of PPARbeta-LBD (unknown origin) assessed as fluorescein-labeled coactivator C33 recruitment by TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to human PPARdelta (unknown origin) by competitive TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  920nMAssay Description:Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  2.90nMAssay Description:Displacement of pan-PPAR fluormone from PPARdelta LBD by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human PPARdelta LBD by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human PPARdelta after 22 to 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human GAL4 fused PPARdelta-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes Of Health

LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataIC50:  2.23E+4nMAssay Description:The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human PPARdelta expressed in nonhuman mammalian cells assessed as increase in receptor transcriptional activity incubated for 22 ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  13nMAssay Description:Transactivation of GAL4-fused human PPARdelta LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
National Institutes Of Health

LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataIC50:  2.23E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human PPAR-deltaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human PPARdelta transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human PPARalpha transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human PPARdelta transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  9.53E+3nMAssay Description:Agonist activity at human PPARgamma transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at pBIND tagged human PPARdelta expressed in human HepG2 cells incubated for 18 hrs by dual luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human PPARdelta expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair