BDBM50135482 1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)-3-methyl-pyrrole-2,5-dione::1-(5-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dione::CHEMBL129857

SMILES: COc1cccc2nc(nc(NN3C(=O)C=C(C)C3=O)c12)-c1cccs1

InChI Key: InChIKey=GZGLPBNOIFLLRE-UHFFFAOYSA-N

Data: 1 KI  8 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50135482   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	618	n/a	n/a	n/a	n/a	n/a	n/a
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Exportin-1 (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
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Transcription factor p65 (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a
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Transcription factor p65 (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
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Transcription factor Jun (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50135482 (1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...) Show SMILES Show InChI	GoogleScholar	UniChem		20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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