BDBM50153534 3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethyl)-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide::CHEMBL178610

SMILES CCN(CC)c1ccc(NC(=O)c2c(CCC3OCCCO3)onc2-c2c(Cl)cccc2Cl)cc1

InChI Key InChIKey=ALRVUGNHBIWQLP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153534   

TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153534(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethy...)
Affinity DataIC50:  19nMAssay Description:Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153534(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO¿K cell FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153534(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of binding to human growth hormone secretagogue receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50153534(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethy...)
Affinity DataIC50:  6nMAssay Description:Ability to displace [125I]-ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed