BDBM50159343 CHEMBL3787394

SMILES COc1ccc(cc1)-c1nnc(o1)C(=O)N1CC(C1)Oc1ccc(CN2CC3(COC3)C2)cc1

InChI Key InChIKey=BKKPIQPFRAPEAY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50159343   

TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50159343(CHEMBL3787394)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human MCHR1 expressed in CHO cell membranes preincubated for 5 mins followed by addition of MCH peptide measured after 45 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50159343(CHEMBL3787394)
Affinity DataIC50:  400nMAssay Description:Inhibition of histamine H3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50159343(CHEMBL3787394)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50159343(CHEMBL3787394)
Affinity DataIC50: >4.00E+4nMAssay Description:Antagonist activity at human MCHR2 expressed in CHO cells after 60 to 75 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50159343(CHEMBL3787394)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of human ERG by IonWork assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed