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BDBM50177932 2-cyano-N-{14-[2-cyano-3-(3,4-dihydroxy-5-methoxyphenyl)acryloylamino]tetradecyl}-3-(3,4-dihydroxy-5-methoxyphenyl)acrylamide::CHEMBL196904

SMILES: COc1cc(\C=C(/C#N)C(=O)NCCCCCCCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O

InChI Key: InChIKey=YHBLYDLXCDLKFU-RYQLWAFASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177932   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-1


(Homo sapiens (Human))
BDBM50177932
PNG
(2-cyano-N-{14-[2-cyano-3-(3,4-dihydroxy-5-methoxyp...)
Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCCCCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O
Show InChI InChI=1S/C34H42N4O8/c1-45-29-19-23(17-27(39)31(29)41)15-25(21-35)33(43)37-13-11-9-7-5-3-4-6-8-10-12-14-38-34(44)26(22-36)16-24-18-28(40)32(42)30(20-24)46-2/h15-20,39-42H,3-14H2,1-2H3,(H,37,43)(H,38,44)/b25-15+,26-16+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair