BindingDB PrimarySearch

BDBM4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414

SMILES: Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl

InChI Key: InChIKey=OMZCMEYTWSXEPZ-UHFFFAOYSA-N

Data: 8 KI 63 IC50 887 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 958 hits for monomerid = 4779
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	550	n/a	n/a	n/a	7.4	25
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Aurora kinase B (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	400	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor [G719C] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.130	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	270	n/a	n/a	n/a	7.4	25
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Ephrin type-B receptor 4 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	730	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 6 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase TNNI3K (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 20 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL2 (Human)	BDBM4779 (cid_156414 \| PD0183805 \| CHEMBL545315 \| CHEMBL3196...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a
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