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BDBM50188306 2-(2,5-dimethyl-3-(6-(trifluoromethyl)quinolin-4-yl)-1H-indol-1-yl)acetic acid::CHEMBL384962

SMILES: Cc1c(-c2ccnc3ccc(cc23)C(F)(F)F)c2cc(C)ccc2n1CC(O)=O

InChI Key: InChIKey=ZCNGPVKGHKYTQX-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188306   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM50188306
PNG
(2-(2,5-dimethyl-3-(6-(trifluoromethyl)quinolin-4-y...)
Show SMILES Cc1c(-c2ccnc3ccc(cc23)C(F)(F)F)c2cc(C)ccc2n1CC(O)=O
Show InChI InChI=1S/C22H17F3N2O2/c1-12-3-6-19-17(9-12)21(13(2)27(19)11-20(28)29)15-7-8-26-18-5-4-14(10-16(15)18)22(23,24)25/h3-10H,11H2,1-2H3,(H,28,29)
PDB

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Similars

Article
PubMed
n/an/a 68n/an/an/an/an/an/a



AstraZeneca R&D Charnwood

Curated by ChEMBL


Assay Description
Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4287-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.062
BindingDB Entry DOI: 10.7270/Q2G44PX7
More data for this
Ligand-Target Pair