BDBM50205897 (+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one::CHEMBL376456

SMILES COc1cccc2C3CNCCN3C(=O)c12

InChI Key InChIKey=AGESLMCHEVXSAE-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205897   

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205897((+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a...)
Affinity DataKi:  133nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205897((+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a...)
Affinity DataKi:  192nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205897((+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a...)
Affinity DataKi:  3.28E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205897((+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205897((+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a...)
Affinity DataEC50:  136nMAssay Description:Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205897((+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a...)
Affinity DataEC50:  207nMAssay Description:Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed