BDBM50227519 4-(6,7-dimethoxyquinazolin-4-ylamino)phenol::CHEMBL405130::CHEMBL555201::US10548897, Compound 7::WHI-P131

SMILES COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC

InChI Key InChIKey=HOZUXBLMYUPGPZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50227519   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Pharmadesign

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of ALK using FL-Peptide 13, 5-FAM-KKSRGDYMTMQIG-CONH2 substrate after 60 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50:  720nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinase suppressor of Ras 2(Human)
Icahn School Of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50227519(4-(6,7-dimethoxyquinazolin-4-ylamino)phenol | CHEM...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
In DepthDetails Article