BDBM50227519 4-(6,7-dimethoxyquinazolin-4-ylamino)phenol::CHEMBL405130::CHEMBL555201::US10548897, Compound 7::WHI-P131
SMILES COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC
InChI Key InChIKey=HOZUXBLMYUPGPZ-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50227519
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of ALK using FL-Peptide 13, 5-FAM-KKSRGDYMTMQIG-CONH2 substrate after 60 mins by mobility shift assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester
Curated by ChEMBL
University Of Manchester
Curated by ChEMBL
Affinity DataIC50: 720nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair