BDBM50246548 CHEMBL462402::rac-2-((methylamino)methyl)-1-(o-tolylthio)-2,3-dihydro-1H-inden-2-ol

SMILES CNCC1(O)Cc2ccccc2C1Sc1ccccc1C

InChI Key InChIKey=RWLJNOQFNVGFMO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50246548   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246548(CHEMBL462402 | rac-2-((methylamino)methyl)-1-(o-to...)
Affinity DataIC50:  10nMAssay Description:Inhibition of norepinephrine uptake at human NET transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246548(CHEMBL462402 | rac-2-((methylamino)methyl)-1-(o-to...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246548(CHEMBL462402 | rac-2-((methylamino)methyl)-1-(o-to...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of dopamine uptake at human DAT transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246548(CHEMBL462402 | rac-2-((methylamino)methyl)-1-(o-to...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed