BDBM60665 BDBM50249542::US9145414, R406::US9212178, R406

SMILES: CC1(C(=O)Nc2c(ccc(n2)Nc3c(cnc(n3)Nc4cc(c(c(c4)OC)OC)OC)F)O1)C

InChI Key: InChIKey=NHHQJBCNYHBUSI-UHFFFAOYSA-N

Data: 1 KI  17 IC50  454 Kd  21 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 498 hits for monomerid = 60665   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.5	n/a	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 2 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Aurora kinase B (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	110	n/a	n/a	n/a	n/a	7.4	25
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23.6	n/a	n/a	n/a	n/a	n/a	25
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Platelet-derived growth factor receptor alpha (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.97E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek3 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek4 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek5 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek6 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek7 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek9 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek11 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase tousled-like 2 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase tousled-like 1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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Adenosine receptor A3 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a
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AP2-associated protein kinase 1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase, smooth muscle (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a
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Death-associated protein kinase 1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 3 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a
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Misshapen-like kinase 1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Myotonin-protein kinase (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM60665 (US9145414, R406 | US9212178, R406 | BDBM50249542 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair