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BDBM50256061 CHEMBL482160::GNF-Pf-4399::N-((5-chloro-8-hydroxyquinolin-7-yl)(4-nitrophenyl)methyl)-2-phenoxyacetamide

SMILES: Oc1c(cc(Cl)c2cccnc12)C(NC(=O)COc1ccccc1)c1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=QIYPSJBTWQBWJK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256061   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50256061
PNG
(CHEMBL482160 | GNF-Pf-4399 | N-((5-chloro-8-hydrox...)
Show SMILES Oc1c(cc(Cl)c2cccnc12)C(NC(=O)COc1ccccc1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C24H18ClN3O5/c25-20-13-19(24(30)23-18(20)7-4-12-26-23)22(15-8-10-16(11-9-15)28(31)32)27-21(29)14-33-17-5-2-1-3-6-17/h1-13,22,30H,14H2,(H,27,29)
PDB
MMDB

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Article
PubMed
n/an/a 460n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of ADAMTS5 by FRET assay


Bioorg Med Chem Lett 18: 6454-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.065
BindingDB Entry DOI: 10.7270/Q25H7G34
More data for this
Ligand-Target Pair