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BDBM50256772 CHEMBL474227::ethyl 2-(4-(4-(dimethylamino)piperidin-1-yl)-6-(4-hydroxypiperidin-1-yl)pyrimidin-2-ylamino)-4-methylthiazole-5-carboxylate

SMILES: CCOC(=O)c1sc(Nc2nc(cc(n2)N2CCC(CC2)N(C)C)N2CCC(O)CC2)nc1C

InChI Key: InChIKey=NWLFMBMMASAEIP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50256772   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50256772
PNG
(CHEMBL474227 | ethyl 2-(4-(4-(dimethylamino)piperi...)
Show SMILES CCOC(=O)c1sc(Nc2nc(cc(n2)N2CCC(CC2)N(C)C)N2CCC(O)CC2)nc1C
Show InChI InChI=1S/C23H35N7O3S/c1-5-33-21(32)20-15(2)24-23(34-20)27-22-25-18(29-10-6-16(7-11-29)28(3)4)14-19(26-22)30-12-8-17(31)9-13-30/h14,16-17,31H,5-13H2,1-4H3,(H,24,25,26,27)
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 19: 1935-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.060
BindingDB Entry DOI: 10.7270/Q2TM7B02
More data for this
Ligand-Target Pair