BDBM50277584 CHEMBL482968::N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

SMILES: CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(C=Cc2ccccc2)n1

InChI Key: InChIKey=BLQYVHBZHAISJM-UHFFFAOYSA-N

Data: 34 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50277584   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	294	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50277584 (N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair