BDBM50312770 (4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-4-yl)methanone::CHEMBL1076586

SMILES O=C(N1CCN(CC1)C(=O)c1ccc2cc[nH]c2c1)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=APHXKHUFVKITGC-UHFFFAOYSA-N

Data  12 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50312770   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D3 rceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2A (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of 5HT2C (receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of alpha2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of dopamine D2 rceptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50312770((4-(1H-indole-6-carbonyl)piperazin-1-yl)(biphenyl-...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash lum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed