BDBM50314764 CHEMBL1093304::trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)propan-2-yl)acetamide

SMILES CC(=O)NC(C)(C)[C@@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12

InChI Key InChIKey=KMNARKQYUZICHM-ZRRKCSAHSA-N

Data  5 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50314764   

TargetMelanocortin receptor 3(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  997nMAssay Description:Agonist activity at rat MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  351nMAssay Description:Agonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  1.02E+3nMAssay Description:Agonist activity at human MC1R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataIC50:  890nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC3R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at mouse MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at mouse MC3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at human MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataIC50:  1.94E+3nMAssay Description:Agonist activity at human MC1R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataIC50:  84nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC5R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at rat MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at mouse MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(CHEMBL1093304 | trans-N-(2-((R)-1'-((3S,4R)-1-tert...)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at human MC4R expressed in CHO cells assessed as increase of alpha-MSH-stimulated cAMP release pretreated for 10 mins before alpha-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed