BDBM50319564 (R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline::CHEMBL1084616

SMILES C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1ccn2ncnc2n1

InChI Key InChIKey=AGDVFPLNDDIXBY-OAHLLOKOSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319564   

TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319564((R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319564((R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319564((R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319564((R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-...)
Affinity DataKi:  5.20E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50319564((R)-2-([1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-6-(2-...)
Affinity DataIC50:  2.08E+4nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed