BDBM50319665 (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one::AMG-221::CHEMBL1085107

SMILES: CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O

InChI Key: InChIKey=YCNCXQNUXCHRRX-UHFFFAOYSA-N

Data: 3 KI  13 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50319665   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase type 2 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glucocorticoid receptor (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase 1 (Mouse)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.66	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		12.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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11-beta-hydroxysteroid dehydrogenase 1 (Human)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		12.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mouse)	BDBM50319665 (AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...) Show SMILES Show InChI	GoogleScholar	UniChem		70.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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