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BDBM50325737 CHEMBL1224343::N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl)methyl)-1-m-tolylethanamine

SMILES: COc1ccc(CNC(C)c2cccc(C)c2)cc1-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=DPVDYMFQKDPRNX-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50325737   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325737
PNG
(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Show SMILES COc1ccc(CNC(C)c2cccc(C)c2)cc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H24F3NO/c1-16-5-4-6-20(13-16)17(2)28-15-18-7-12-23(29-3)22(14-18)19-8-10-21(11-9-19)24(25,26)27/h4-14,17,28H,15H2,1-3H3
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 430n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
BindingDB Entry DOI: 10.7270/Q2Z89CM3
More data for this
Ligand-Target Pair
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))
BDBM50325737
PNG
(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Show SMILES COc1ccc(CNC(C)c2cccc(C)c2)cc1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H24F3NO/c1-16-5-4-6-20(13-16)17(2)28-15-18-7-12-23(29-3)22(14-18)19-8-10-21(11-9-19)24(25,26)27/h4-14,17,28H,15H2,1-3H3
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 160n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium


Bioorg Med Chem Lett 20: 5544-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.060
BindingDB Entry DOI: 10.7270/Q2Z89CM3
More data for this
Ligand-Target Pair