BDBM50333491 (R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopentanecarboxamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid::CHEMBL1641817

SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CCCC1)c1ccc(F)cc1

InChI Key InChIKey=BLYMEBNUHVMONG-LJQANCHMSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50333491   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333491((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Affinity DataKi:  3.90nMAssay Description:Displacement of radioligand from human CRTH2 expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333491((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Affinity DataKi: >4.00E+3nMAssay Description:Displacement of radioligand from prostanoid DP receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333491((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Affinity DataKi: >7.20E+3nMAssay Description:Displacement of radioligand from prostanoid TP receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333491((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at CRTH2 in human eosinophil assessed as effect of cellular shape change by EOS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333491((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopentanec...)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at human CRTH2 expressed in HEK293 cells assessed as inhibition of forskolin-induced increase intracellular [125I]cAMP level by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed