BDBM50336843 3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile::CHEMBL1672288

SMILES: Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N

InChI Key: InChIKey=LVXAMCKZCLWWTF-UHFFFAOYSA-N

Data: 47 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50336843   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rat)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Muscarinic acetylcholine receptor M4 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Kappa-type opioid receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histamine H1 receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histamine H2 receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histamine H4 receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Metabotropic glutamate receptor 4 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sodium-dependent serotonin transporter (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Sigma non-opioid intracellular receptor 1 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 6 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Alpha-2B adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1D (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 1E (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2C (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 5A (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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D(3) dopamine receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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5-hydroxytryptamine receptor 7 (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Alpha-1B adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1D adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Alpha-2A adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-2C adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-1 adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Delta-type opioid receptor (Human)	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair