BDBM50337957 (4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)methanone::CHEMBL1684241

SMILES OC1CCN(CC1)C(=O)c1ccc(cc1)C#Cc1ccccc1

InChI Key InChIKey=FPDBSDNGFNDSSK-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50337957   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337957((4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)...)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337957((4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu3 assessed as assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337957((4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)...)
Affinity DataEC50:  270nMAssay Description:Positive allosteric modulation of rat mGlu5 expressed in HEK293 cells in presence of glutamate EC20 concentration by Fluo-2AM dye based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed