BDBM50337958 CHEMBL1684242::N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide

SMILES Fc1cccc(c1)C#Cc1ccc(cn1)C(=O)NC1CCC1

InChI Key InChIKey=NEMHWVUKNWAKTM-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50337958   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(CHEMBL1684242 | N-cyclobutyl-6-((3-fluorophenyl)et...)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(CHEMBL1684242 | N-cyclobutyl-6-((3-fluorophenyl)et...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337958(CHEMBL1684242 | N-cyclobutyl-6-((3-fluorophenyl)et...)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed