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BDBM50341111 (4-(2-methoxyphenyl)piperazin-1-yl)(3-(pyridin-3-yl)-1H-pyrazol-5-yl)methanone::CHEMBL1760215

SMILES: COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1cccnc1

InChI Key: InChIKey=MXFKJSGGUQBBBR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50341111   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341111
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(pyridin-3-y...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1cccnc1
Show InChI InChI=1S/C20H21N5O2/c1-27-19-7-3-2-6-18(19)24-9-11-25(12-10-24)20(26)17-13-16(22-23-17)15-5-4-8-21-14-15/h2-8,13-14H,9-12H2,1H3,(H,22,23)
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Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair