BDBM50343725 (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile::CHEMBL1774055

SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)cc1C#N)c1ccc(F)cc1

InChI Key InChIKey=SUNXHXDJOIXABJ-NSHDSACASA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50343725   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of JAK2 V617F mutant (unknown origin) using L-Ahx-IPTSPITTTYFFFKKK-COOH as substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50:  151nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1/2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50:  302nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50:  6.61E+3nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed