BDBM50345287 CHEMBL1782534::Ethyl 6-[4-(anilinocarbonyl)piperazin-1-yl]-5-cyano-2-(trifluoromethyl)nicotinate

SMILES CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N1CCN(CC1)C(=O)Nc1ccccc1

InChI Key InChIKey=FITGQXXEPJPWLF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50345287   

TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345287(CHEMBL1782534 | Ethyl 6-[4-(anilinocarbonyl)pipera...)
Affinity DataIC50:  680nMAssay Description:Antagonist activity at P2Y12 receptor (unknown origin) assessed as inhibition of GTPgammaS binding after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345287(CHEMBL1782534 | Ethyl 6-[4-(anilinocarbonyl)pipera...)
Affinity DataIC50:  320nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345287(CHEMBL1782534 | Ethyl 6-[4-(anilinocarbonyl)pipera...)
Affinity DataIC50:  680nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345287(CHEMBL1782534 | Ethyl 6-[4-(anilinocarbonyl)pipera...)
Affinity DataIC50:  330nMAssay Description:Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed