BDBM50345438 6-ethyl-5-methyl-N-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine::CHEMBL1784715::US9238653, Table 5, Compound 9

SMILES CCc1c(C)nc2ncnn2c1Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=ASDLKSYAGDCGAT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50345438   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM50345438(6-ethyl-5-methyl-N-(4-(trifluoromethoxy)phenyl)-[1...)
Affinity DataIC50:  3.17E+3nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345438(6-ethyl-5-methyl-N-(4-(trifluoromethoxy)phenyl)-[1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of His6-tagged recombinant human dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as substrate after 10 t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50345438(6-ethyl-5-methyl-N-(4-(trifluoromethoxy)phenyl)-[1...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed