BDBM50350248 CHEMBL1812545
SMILES Fc1ccc2c(C=Cc3nnn[nH]3)c[nH]c2c1
InChI Key InChIKey=JDBSZVDIUIRSDG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50350248
Affinity DataKi: 5.50E+3nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.60E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli using L-Trp as substrate after 10 to 60 minsMore data for this Ligand-Target Pair
Affinity DataKi: 5.60E+3nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
Affinity DataKi: 7.47E+3nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysisMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysisMore data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 671nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of human recombinant pEF6/V5-His-tagged TDO2 transfected in HEK293-EBNA cells using L-tryptophan as substrate by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 using L-Trp as substrate incubated for 30 mins by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptopha...More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of human TDO2 expressed in mouse P815B cells assessed as kynurenine concentration formation using L-tryptophan as substrate incubated for ...More data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition of mouse IDO1More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of mouse TDOMore data for this Ligand-Target Pair