BDBM50364326 CHEMBL1949930

SMILES COc1cc(OC(C)C)cc(c1)S(=O)(=O)c1ccc2[C@@H]3CCNC[C@@H]3Oc2c1

InChI Key InChIKey=DIBPTWMSVTXGKP-FPOVZHCZSA-N

Data  7 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50364326   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]LSD from rat recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]LSD from rat recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human 5HT2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibition of human 5HT2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of human 5HT2CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of NA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50: >5.90E+3nMAssay Description:Inhibition of CYP 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in human astrocytoma cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in human astrocytoma cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataIC50: >2.29E+4nMAssay Description:Inhibition of CYP 2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed