BDBM50377352 BMS-645737::CHEMBL261592

SMILES CC(C)c1c(cn2ncnc(Nc3cnc4[nH]c(C)cc4c3)c12)-c1nnc(C)o1

InChI Key InChIKey=OOQXPATWSOGSAV-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50377352   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50:  25nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50:  53nMAssay Description:Inhibition of mouse Flk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50:  268nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50:  78nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed