BDBM53933 (5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-2-phenyl-2-thiazolin-4-one::(5Z)-5-[(3-chloranyl-5-methoxy-4-oxidanyl-phenyl)methylidene]-2-phenyl-1,3-thiazol-4-one::(5Z)-5-[(3-chloro-4-hydroxy-5-methoxyphenyl)methylidene]-2-phenyl-1,3-thiazol-4-one::(5Z)-5-[(3-chloro-4-hydroxy-5-methoxyphenyl)methylidene]-2-phenyl-4-thiazolone::5-(3-chloro-4-hydroxy-5-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one::5-(3-chloro-4-hydroxy-5-methoxybenzylidene)-2-phenylthiazol-4(5H)-one::CHEMBL1339294::MLS000676732::SMR000298378::cid_717270

SMILES COc1cc(\C=C2/SC(=NC2=O)c2ccccc2)cc(Cl)c1O

InChI Key InChIKey=BTIAAMWQYVYEFI-ZROIWOOFSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 53933   

TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM53933((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM53933((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM53933((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM53933((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM53933((5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed