BDBM7885 1-benzyl-2-methyl-1H-imidazole::US9138393, 1-benzyl-2-methylimidazole::US9144538, 1-benzyl-2-methylimidazole

SMILES Cc1nccn1Cc1ccccc1

InChI Key InChIKey=FBHPRUXJQNWTEW-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7885   

TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7885(1-benzyl-2-methyl-1H-imidazole | US9138393, 1-benz...)
Affinity DataKi:  1.65E+5nM ΔG°:  -5.24kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Università

Curated by ChEMBL
LigandPNGBDBM7885(1-benzyl-2-methyl-1H-imidazole | US9138393, 1-benz...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of mouse macrophage iNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Università

Curated by ChEMBL
LigandPNGBDBM7885(1-benzyl-2-methyl-1H-imidazole | US9138393, 1-benz...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of bovine eNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM7885(1-benzyl-2-methyl-1H-imidazole | US9138393, 1-benz...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat brain nNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM7885(1-benzyl-2-methyl-1H-imidazole | US9138393, 1-benz...)
Affinity DataIC50:  3.08E+5nMpH: 7.4 T: 2°CAssay Description:Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM7885(1-benzyl-2-methyl-1H-imidazole | US9138393, 1-benz...)
Affinity DataIC50:  3.08E+5nMpH: 7.4Assay Description:All procedures were carried out under minimal light in order to prevent degradation of the retinoid samples.Microsomal preparation: one lobe of fresh...More data for this Ligand-Target Pair
In DepthDetails US Patent