BDBM97406 Orexin receptor antagonist 1::US20130102619, 1

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(ccn1)C#N

InChI Key InChIKey=FOEWIXNBXKVERV-NVXWUHKLSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 97406   

TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataKi:  1.60nMAssay Description:The inhibition constant (ki) is determined using a radioligand assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-(S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataKi:  813nMAssay Description:The inhibition constant (ki) is determined using a radioligand assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataKi:  829nMAssay Description:Displacement of [3H](S)-N-(biphenyl-2-yl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX1R expressed in C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataKi:  830nMAssay Description:Displacement of [3H]-(S)-N-(biphenyl-2-yl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX1R expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataIC50:  3.20E+3nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as reduction in orexin A-induced calcium flux preincubated followed by orexin A a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataIC50:  12nMT: 2°CAssay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human OX2R expressed in CHOK1 cells assessed as reduction in orexin A-induced calcium flux preincubated followed by orexin A a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataIC50:  3.80E+3nMAssay Description:Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataIC50:  3.65E+3nMT: 2°CAssay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM97406(Orexin receptor antagonist 1 | US20130102619, 1)
Affinity DataIC50:  13nMAssay Description:Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed