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Found 50 with Last Name = 'pease' and Initial = 'b'
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232529(5-(2-fluorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232565((S)-5-(1-(3-chlorophenyl)ethoxy)quinazoline-2,4-di...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232535(5-(1-(3-chlorophenyl)ethoxy)quinazoline-2,4-diamin...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294161((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)pyrro...)
Affinity DataIC50:  69nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294161((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)pyrro...)
Affinity DataIC50:  71nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294162((R)-(4-(pyrrolidin-2-ylmethoxy)phenyl)(4-(thiophen...)
Affinity DataIC50:  81nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294163((R)-N-benzyl-4-(pyrrolidin-2-ylmethoxy)aniline | C...)
Affinity DataIC50:  157nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294162((R)-(4-(pyrrolidin-2-ylmethoxy)phenyl)(4-(thiophen...)
Affinity DataIC50:  189nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294163((R)-N-benzyl-4-(pyrrolidin-2-ylmethoxy)aniline | C...)
Affinity DataIC50:  207nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232538(5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50:  9.38E+3nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294164(1-(2,2'-bithiophen-5-yl)methanamine | 2,2'-bithiop...)
Affinity DataIC50:  3.89E+4nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232527(5-((1-(3-chlorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50:  5.52E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294164(1-(2,2'-bithiophen-5-yl)methanamine | 2,2'-bithiop...)
Affinity DataIC50:  7.52E+4nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50:  9.80E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294165((4-(thiophen-2-yl)phenyl)methanamine | 1-(4-thioph...)
Affinity DataIC50:  1.06E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294165((4-(thiophen-2-yl)phenyl)methanamine | 1-(4-thioph...)
Affinity DataIC50:  1.06E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232561(5-((1-(2-fluorophenylsulfonyl)piperidin-4-yl)metho...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232538(5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232571((2-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232541((3-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | 5-(4-hydroxyphenethyl)...)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294166(CHEMBL558285 | pyridin-4-yl(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  1.70E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294166(CHEMBL558285 | pyridin-4-yl(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  2.02E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  2.12E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294167(5-(2-(pyrrolidin-1-yl)ethoxy)-1H-indole | CHEMBL56...)
Affinity DataIC50:  2.34E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | 5-(4-hydroxyphenethyl)...)
Affinity DataIC50:  2.47E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  3.08E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294167(5-(2-(pyrrolidin-1-yl)ethoxy)-1H-indole | CHEMBL56...)
Affinity DataIC50:  3.21E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  3.66E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  6.19E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294168(1-(2-(1H-indol-5-yloxy)ethyl)piperidine-4-carboxyl...)
Affinity DataIC50:  9.66E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294169(5-chloro-1H-indole | CHEMBL555013)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM32212(1H-indol-5-ol | cid_16054)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294170(5-fluoro-1H-indole | CHEMBL555457)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50293592(4-(2-Aminothiazol-4-yl)phenol | 4-(2-amino-1,3-thi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294171(CHEMBL549343 | N-methyl-1-(2-(thiophen-2-yl)phenyl...)
Affinity DataIC50:  1.08E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294172(CHEMBL264669 | N-(pyridin-3-ylmethyl)aniline | N-(...)
Affinity DataIC50:  1.32E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50293592(4-(2-Aminothiazol-4-yl)phenol | 4-(2-amino-1,3-thi...)
Affinity DataIC50:  1.44E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294168(1-(2-(1H-indol-5-yloxy)ethyl)piperidine-4-carboxyl...)
Affinity DataIC50:  1.49E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294169(5-chloro-1H-indole | CHEMBL555013)
Affinity DataIC50:  1.51E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294172(CHEMBL264669 | N-(pyridin-3-ylmethyl)aniline | N-(...)
Affinity DataIC50:  1.67E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM32212(1H-indol-5-ol | cid_16054)
Affinity DataIC50: >2.00E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294170(5-fluoro-1H-indole | CHEMBL555457)
Affinity DataIC50: >2.00E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294171(CHEMBL549343 | N-methyl-1-(2-(thiophen-2-yl)phenyl...)
Affinity DataIC50: >2.00E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294173((4-fluorophenyl)(pyridin-4-yl)methanone | CHEMBL56...)
Affinity DataIC50:  3.67E+6nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50294173((4-fluorophenyl)(pyridin-4-yl)methanone | CHEMBL56...)
Affinity DataIC50:  5.31E+6nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair