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Target
Beta-2 adrenergic receptor
Ligand
BDBM86453
Substrate
n/a
Meas. Tech.
ChEMBL_756114 (CHEMBL1804370)
EC50
0.501187±n/a nM
Citation
 Stocks, MJ; Alcaraz, L; Bailey, A; Bonnert, R; Cadogan, E; Christie, J; Connolly, S; Cook, A; Fisher, A; Flaherty, A; Hill, S; Humphries, A; Ingall, A; Jordan, S; Lawson, M; Mullen, A; Nicholls, D; Paine, S; Pairaudeau, G; St-Gallay, S; Young, A Design driven HtL: The discovery and synthesis of new high efficacyß2-agonists. Bioorg Med Chem Lett 21:4027-31 (2011) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM86453
Synonyms:
CAS_73573-87-2 | Formoterol | NSC_3083544
Type:
Small organic molecule
Emp. Form.:
C19H24N2O4
Mol. Mass.:
344.4049
SMILES:
COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1
Structure:
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