BDBM50104891 7-Hydroxy-4-phenyl-chromen-2-one::7-hydroxy-4-phenyl-2H-chromen-2-one::CHEMBL325841::Coumarin derivative, 3c::cid_5357479

SMILES Oc1ccc2c(cc(=O)oc2c1)-c1ccccc1

InChI Key InChIKey=IVJMJRRORVMRJJ-UHFFFAOYSA-N

Data  4 KI  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50104891   

TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataKi:  47nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataKi:  91nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition human recombinant aldose reductase 1 by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSorbitol dehydrogenase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  7.07E+4nMAssay Description:Inhibition sorbitol dehydrogenase by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  2.58E+5nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase precursor(Danio rerio)
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  1.03E+5nMAssay Description:Inhibition of zebrafish embryo tyrosinase assessed as melanin production after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase precursor(Danio rerio)
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  2.05E+5nMAssay Description:Inhibition of zebrafish embryo tyrosinase assessed as residual activity after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 3(Homo sapiens (Human))
Sumitomo Chemical

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human 17beta-HSD3 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Umdnj-New Jersey Medical School

LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataIC50:  4.16E+4nMpH: 7.0 T: 2°CAssay Description:Inhibition assay using HCV NS5B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock factor protein 1(Mus musculus)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataEC50:  1.17E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50104891(7-Hydroxy-4-phenyl-chromen-2-one | 7-hydroxy-4-phe...)
Affinity DataEC50:  2.46E+4nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay