BDBM50181914 2-(2-Fluoro-biphenyl-4-yl)-2-methyl-propionic acid::CHEMBL380853

SMILES CC(C)(C(O)=O)c1ccc(c(F)c1)-c1ccccc1

InChI Key InChIKey=UTJOTVGFUYHIRG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50181914   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50181914(2-(2-Fluoro-biphenyl-4-yl)-2-methyl-propionic acid...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50181914(2-(2-Fluoro-biphenyl-4-yl)-2-methyl-propionic acid...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of COX2-mediated 2-arachidonoylglycerol oxygenation in LPS/IFN-gamma-stimulated mouse RAW264.7 cells assessed as 2-AG to PGE2-G/PGD2-G con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50181914(2-(2-Fluoro-biphenyl-4-yl)-2-methyl-propionic acid...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of mouse COX2-mediated 2-arachidonoylglycerol oxygenation preincubated for 3 mins before 2-arachidonoylglycerol addition measured after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed