BDBM50396243 CHEMBL2172308::US10370379, Compound TSR-011

SMILES: CC(C)NC(=O)[C@H]1CC[C@H](CC1)n1c(NC(=O)c2ccc(F)cc2)nc2ccc(CN3CCC(CC3)C(C)(C)O)cc12

InChI Key: InChIKey=WSTUJEXAPHIEIM-UHFFFAOYSA-N

Data: 8 IC50  8 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50396243   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
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NT-3 growth factor receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
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ALK tyrosine kinase receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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ALK tyrosine kinase receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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ALK tyrosine kinase receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 2 (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
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Leukocyte tyrosine kinase receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 1 (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor UFO (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	231	n/a	n/a	n/a	n/a	n/a	n/a
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ALK tyrosine kinase receptor (Human)	BDBM50396243 (CHEMBL2172308 | US10370379, Compound TSR-011) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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