BDBM31044 1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1-ethyl-6-methyl-3-(2-thienyl)pyrimido[5,4-e][1,2,4]triazine-5,7-quinone::1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1-ethyl-6-methyl-3-thiophen-2-ylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::MLS000033110::SMR000008918::US9073941, 610::cid_653297

SMILES: CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1cccs1

InChI Key: InChIKey=DMDNERFCUCYCGM-UHFFFAOYSA-N

Data: 38 IC50  2 Kd  5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 31044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	552	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroidogenic factor 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2) (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Steroidogenic factor 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	421	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 6 (Rat)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	629	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	333	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2) (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 3 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	815	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cathepsin B (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Procathepsin L (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	309	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cathepsin S (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	257	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Procathepsin L (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 6 (Rat)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrolipoyl dehydrogenase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<40	n/a	n/a	n/a	n/a	7.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<40	n/a	n/a	n/a	n/a	7.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Diphosphomevalonate decarboxylase (Streptococcus pneumoniae D39)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	629	n/a	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	7.0	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cathepsin B (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72.2	n/a	n/a	n/a	n/a	6.8	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	365	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	308	n/a	n/a	n/a	8.0	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heat shock protein HSP 90-beta (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.21E+3	n/a	n/a	n/a	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.18E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	421	n/a	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 6 (Rat)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mevalonate kinase (Streptococcus pneumoniae D39)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mevalonate kinase (Streptococcus pneumoniae D39)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mevalonate kinase (Streptococcus pneumoniae D39)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 1 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 6 (Rat)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein phosphatase 6 (Rat)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	445	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
M-phase inducer phosphatase 2 (Human)	BDBM31044 (1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	542	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair