BDBM50049181 2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-biphenyl-4-ylmethyl)-6-(N-isopropyl-N-methyl-aminocarbonylamino)-3H-quinazolin-4-one::4'-[2-Butyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-4H-quinazolin-3-ylmethyl]-biphenyl-2-sulfonic acid butyloxycarbonylamide(LP-162,393)::CHEMBL74476::L-162393::Quinazolinone Analog

SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1

InChI Key InChIKey=AEJPLKVXLXBIJD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50049181   

TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  0.240nMAssay Description:Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  60nMAssay Description:In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  2.40nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  0.240nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-2 angiotensin II receptor(RAT)
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  2.40nMAssay Description:In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rat adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails Article