BindingDB PrimarySearch

BDBM82507 (+/-)-Methadone::CAS_5967-73-7::METHADONE::Methadone-HCL,(-)::NSC_22266

SMILES: CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1

InChI Key: InChIKey=USSIQXCVUWKGNF-UHFFFAOYSA-N

Data: 31 KI 8 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 82507
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Universities of Lille Curated by ChEMBL					Assay Description Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand				J Med Chem 44: 3378-90 (2001) Article DOI: 10.1021/jm010877o BindingDB Entry DOI: 10.7270/Q23X87B8
Universities of Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting				J Med Chem 21: 600-6 (1978) Article DOI: 10.1021/jm00205a003 BindingDB Entry DOI: 10.7270/Q2WM1HDV
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	512	n/a	n/a	n/a	n/a	n/a	n/a
Universities of Lille Curated by ChEMBL					Assay Description Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand				J Med Chem 44: 3378-90 (2001) Article DOI: 10.1021/jm010877o BindingDB Entry DOI: 10.7270/Q23X87B8
Universities of Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universities of Lille Curated by ChEMBL					Assay Description Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand				J Med Chem 44: 3378-90 (2001) Article DOI: 10.1021/jm010877o BindingDB Entry DOI: 10.7270/Q23X87B8
Universities of Lille Curated by ChEMBL					More data for this Ligand-Target Pair
P-glycoprotein 1 (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tufts University School of Medicine Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of Rhodamine 123 transepithelial transport (basal to apical) (Rhodamine 123: 5 uM) in Caco-2 cells				Drug Metab Dispos 29: 954-6 (2001) BindingDB Entry DOI: 10.7270/Q2HQ4164
Tufts University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Reverse proteomics research institute Curated by ChEMBL					Assay Description Inhibitory concentration against potassium channel HERG				Bioorg Med Chem Lett 15: 2886-90 (2005) Article DOI: 10.1016/j.bmcl.2005.03.080 BindingDB Entry DOI: 10.7270/Q29S1S7C
Reverse proteomics research institute Curated by ChEMBL					More data for this Ligand-Target Pair
Voltage-gated L-type calcium channel (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
ChanTest Corporation Curated by ChEMBL					Assay Description Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits				Sci Rep 3: (2013) Article DOI: 10.1038/srep02100 BindingDB Entry DOI: 10.7270/Q2RB77K2
ChanTest Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.13E+7	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting				J Med Chem 21: 600-6 (1978) Article DOI: 10.1021/jm00205a003 BindingDB Entry DOI: 10.7270/Q2WM1HDV
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	19.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	0.720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by PDSP K_i Database									Mol Pharmacol 45: 330-4 (1994) BindingDB Entry DOI: 10.7270/Q21Z42X1
University of Pennsylvania Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 1246-55 (1994) BindingDB Entry DOI: 10.7270/Q2CF9NN9
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	15.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 1246-55 (1994) BindingDB Entry DOI: 10.7270/Q2CF9NN9
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	1.45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 1246-55 (1994) BindingDB Entry DOI: 10.7270/Q2CF9NN9
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 423-8 (1995) BindingDB Entry DOI: 10.7270/Q2TM78M9
University of Pennsylvania Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 423-8 (1995) BindingDB Entry DOI: 10.7270/Q2TM78M9
University of Pennsylvania Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by PDSP K_i Database									Mol Pharmacol 45: 330-4 (1994) BindingDB Entry DOI: 10.7270/Q21Z42X1
University of Pennsylvania Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by PDSP K_i Database									Mol Pharmacol 45: 330-4 (1994) BindingDB Entry DOI: 10.7270/Q21Z42X1
University of Pennsylvania Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	14.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	992	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Norepinephrine transporter (RAT)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	702	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Norepinephrine transporter (RAT)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Opioid receptors; mu & delta (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	435	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	132	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
OPRD1 (GUINEA PIG)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	37.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	324	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	728	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mu-type opioid receptor (GUINEA PIG)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SRI International Curated by PDSP K_i Database									NIDA Res Monogr 178: 440-66 (1998) BindingDB Entry DOI: 10.7270/Q23J3BH2
SRI International Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mas-related G protein-coupled receptor X2 (MRGPRX2) (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.40E+4	n/a	n/a	7.4	30
University of North Carolina					Assay Description HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...				Nat Chem Biol 13: 529-536 (2017) Article DOI: 10.1038/nchembio.2334 BindingDB Entry DOI: 10.7270/Q20R9N82
University of North Carolina					More data for this Ligand-Target Pair
Cytochrome P450 2B6 (Homo sapiens (Human))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	DrugBank Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inactivation of C-terminal His4-tagged human CYP2B6 lacking 21 N-terminal residues expressed in Escherichia coli C41 (DE3) assessed as decreases in f...				Drug Metab Dispos 40: 1765-70 (2012) Article DOI: 10.1124/dmd.112.045971 BindingDB Entry DOI: 10.7270/Q21V5GP6
University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Aldehyde oxidase (Rattus norvegicus)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of rat aldehyde oxidase				J Med Chem 53: 8441-60 (2010) Article DOI: 10.1021/jm100888d BindingDB Entry DOI: 10.7270/Q2057G6G
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	0.945	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	405	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Opioid receptors; mu & delta (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	960	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
Opioid receptors; mu & delta (Rattus norvegicus (rat))	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	371	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. W. Johnson Pharmaceutical Research Institute Curated by PDSP K_i Database									J Pharmacol Exp Ther 274: 1263-70 (1995) BindingDB Entry DOI: 10.7270/Q2R20ZVX
					More data for this Ligand-Target Pair
DRD1 (BOVINE)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 800-12 (1976) BindingDB Entry DOI: 10.7270/Q22B8WH6
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM82507 ((+/-)-Methadone \| CAS_5967-73-7 \| METHADONE \| Meth...) Show SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI DrugBank KEGG PC cid PC sid UniChem Similars	PubMed	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 800-12 (1976) BindingDB Entry DOI: 10.7270/Q22B8WH6
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair