BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 63 hits of ec50 data for polymerid = 50006345   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428001
PNG
(CHEMBL2322627)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cccs1
Show InChI InChI=1S/C23H18N4O2S3/c28-20(26-19-9-8-15(13-24-19)18-7-4-11-30-18)14-32-23-25-17-10-12-31-21(17)22(29)27(23)16-5-2-1-3-6-16/h1-9,11,13H,10,12,14H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428009
PNG
(CHEMBL2323230)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-18-11-12-20(26-15-18)17-7-3-1-4-8-17)16-33-25-28-21-13-14-32-23(21)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428011
PNG
(CHEMBL2323228)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-19-10-8-17(9-11-19)18-5-4-13-26-15-18)16-33-25-28-21-12-14-32-23(21)24(31)29(25)20-6-2-1-3-7-20/h1-11,13,15H,12,14,16H2,(H,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.450n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428008
PNG
(CHEMBL2323231)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428015
PNG
(CHEMBL2322632)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H21N3O2S2/c30-23(27-20-13-11-19(12-14-20)18-7-3-1-4-8-18)17-33-26-28-22-15-16-32-24(22)25(31)29(26)21-9-5-2-6-10-21/h1-14H,15-17H2,(H,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.75n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428006
PNG
(CHEMBL2323233)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cccnc1
Show InChI InChI=1S/C24H19N5O2S2/c30-21(28-20-9-8-17(14-26-20)16-5-4-11-25-13-16)15-33-24-27-19-10-12-32-22(19)23(31)29(24)18-6-2-1-3-7-18/h1-9,11,13-14H,10,12,15H2,(H,26,28,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428000
PNG
(CHEMBL2322628)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccoc1
Show InChI InChI=1S/C22H17N5O3S2/c28-18(26-21-23-10-15(11-24-21)14-6-8-30-12-14)13-32-22-25-17-7-9-31-19(17)20(29)27(22)16-4-2-1-3-5-16/h1-6,8,10-12H,7,9,13H2,(H,23,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428004
PNG
(CHEMBL2322624)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccoc1
Show InChI InChI=1S/C23H18N4O3S2/c28-20(26-19-7-6-15(12-24-19)16-8-10-30-13-16)14-32-23-25-18-9-11-31-21(18)22(29)27(23)17-4-2-1-3-5-17/h1-8,10,12-13H,9,11,14H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428002
PNG
(CHEMBL2322626)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccsc1
Show InChI InChI=1S/C23H18N4O2S3/c28-20(26-19-7-6-15(12-24-19)16-8-10-30-13-16)14-32-23-25-18-9-11-31-21(18)22(29)27(23)17-4-2-1-3-5-17/h1-8,10,12-13H,9,11,14H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428010
PNG
(CHEMBL2323229)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-19-8-6-17(7-9-19)18-10-13-26-14-11-18)16-33-25-28-21-12-15-32-23(21)24(31)29(25)20-4-2-1-3-5-20/h1-11,13-14H,12,15-16H2,(H,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428003
PNG
(CHEMBL2322625)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccco1
Show InChI InChI=1S/C23H18N4O3S2/c28-20(26-19-9-8-15(13-24-19)18-7-4-11-30-18)14-32-23-25-17-10-12-31-21(17)22(29)27(23)16-5-2-1-3-6-16/h1-9,11,13H,10,12,14H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50427999
PNG
(CHEMBL2322629)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccco1
Show InChI InChI=1S/C22H17N5O3S2/c28-18(26-21-23-11-14(12-24-21)17-7-4-9-30-17)13-32-22-25-16-8-10-31-19(16)20(29)27(22)15-5-2-1-3-6-15/h1-7,9,11-12H,8,10,13H2,(H,23,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428012
PNG
(CHEMBL2322635)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-18-11-9-17(10-12-18)20-8-4-5-14-26-20)16-33-25-28-21-13-15-32-23(21)24(31)29(25)19-6-2-1-3-7-19/h1-12,14H,13,15-16H2,(H,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428005
PNG
(CHEMBL2322623)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cncnc1
Show InChI InChI=1S/C23H18N6O2S2/c30-20(28-19-7-6-15(12-26-19)16-10-24-14-25-11-16)13-33-23-27-18-8-9-32-21(18)22(31)29(23)17-4-2-1-3-5-17/h1-7,10-12,14H,8-9,13H2,(H,26,28,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 5.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428042
PNG
(CHEMBL2324275)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H18ClN5O4S/c1-35-16-9-7-15(8-10-16)31-24(34)18-5-3-2-4-17(18)22(30-31)23(33)27-13-21(32)29-25-28-19-11-6-14(26)12-20(19)36-25/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM37088
PNG
(2-[(3,6-dimethyl-4-oxidanylidene-6,7-dihydrothieno...)
Show SMILES CC1Cc2nc(SCC(=O)Nc3nc4ccc(C)cc4s3)n(C)c(=O)c2S1
Show InChI InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428007
PNG
(CHEMBL2323232)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H19N5O2S2/c30-20(28-23-25-13-17(14-26-23)16-7-3-1-4-8-16)15-33-24-27-19-11-12-32-21(19)22(31)29(24)18-9-5-2-6-10-18/h1-10,13-14H,11-12,15H2,(H,25,26,28,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428050
PNG
(CHEMBL2322622)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(C)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C26H21N5O4S/c1-15-7-12-20-21(13-15)36-26(28-20)29-22(32)14-27-24(33)23-18-5-3-4-6-19(18)25(34)31(30-23)16-8-10-17(35-2)11-9-16/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428027
PNG
(CHEMBL1257090)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428043
PNG
(CHEMBL2324274)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C24H15ClFN5O3S/c25-13-5-10-18-19(11-13)35-24(28-18)29-20(32)12-27-22(33)21-16-3-1-2-4-17(16)23(34)31(30-21)15-8-6-14(26)7-9-15/h1-11H,12H2,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428044
PNG
(CHEMBL2324273)
Show SMILES Clc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16ClN5O3S/c25-14-10-11-18-19(12-14)34-24(27-18)28-20(31)13-26-22(32)21-16-8-4-5-9-17(16)23(33)30(29-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428016
PNG
(CHEMBL2323243)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C25H26N4O2S2/c30-22(26-18-9-11-19(12-10-18)28-14-5-2-6-15-28)17-33-25-27-21-13-16-32-23(21)24(31)29(25)20-7-3-1-4-8-20/h1,3-4,7-12H,2,5-6,13-17H2,(H,26,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428028
PNG
(CHEMBL1257064)
Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428033
PNG
(CHEMBL2325505)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C23H17F3N4O3S3/c1-33-16-5-3-2-4-15(16)30-20(32)19-14(8-9-34-19)28-22(30)35-11-18(31)29-21-27-13-7-6-12(23(24,25)26)10-17(13)36-21/h2-7,10H,8-9,11H2,1H3,(H,27,29,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428052
PNG
(CHEMBL2322620)
Show SMILES Cc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H19N5O3S/c1-15-11-12-19-20(13-15)34-25(27-19)28-21(31)14-26-23(32)22-17-9-5-6-10-18(17)24(33)30(29-22)16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 35n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428038
PNG
(CHEMBL2325512)
Show SMILES COc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C22H17ClN4O3S3/c1-30-14-5-3-13(4-6-14)27-20(29)19-16(8-9-31-19)25-22(27)32-11-18(28)26-21-24-15-7-2-12(23)10-17(15)33-21/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 35n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50365355
PNG
(CHEMBL1257089)
Show SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1
Show InChI InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428056
PNG
(CHEMBL2324277)
Show SMILES COc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C22H18N4O3S3/c1-29-14-7-8-15-17(11-14)32-21(23-15)25-18(27)12-31-22-24-16-9-10-30-19(16)20(28)26(22)13-5-3-2-4-6-13/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428041
PNG
(CHEMBL2325509)
Show SMILES Clc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C21H15ClN4O2S3/c22-12-6-7-14-16(10-12)31-20(23-14)25-17(27)11-30-21-24-15-8-9-29-18(15)19(28)26(21)13-4-2-1-3-5-13/h1-7,10H,8-9,11H2,(H,23,25,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428035
PNG
(CHEMBL2324266)
Show SMILES FC(F)(F)c1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
Show InChI InChI=1S/C22H15F3N4O2S3/c23-22(24,25)12-6-7-14-16(10-12)34-20(26-14)28-17(30)11-33-21-27-15-8-9-32-18(15)19(31)29(21)13-4-2-1-3-5-13/h1-7,10H,8-9,11H2,(H,26,28,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 40n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428054
PNG
(CHEMBL2324279)
Show SMILES COc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3OC)sc2c1
Show InChI InChI=1S/C23H20N4O4S3/c1-30-13-7-8-14-18(11-13)34-22(24-14)26-19(28)12-33-23-25-15-9-10-32-20(15)21(29)27(23)16-5-3-4-6-17(16)31-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 50n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428039
PNG
(CHEMBL2325511)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C22H17ClN4O3S3/c1-30-16-5-3-2-4-15(16)27-20(29)19-14(8-9-31-19)25-22(27)32-11-18(28)26-21-24-13-7-6-12(23)10-17(13)33-21/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 50n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428020
PNG
(CHEMBL2323239)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C23H18N4O2S3/c28-19(26-22-24-13-18(32-22)15-7-3-1-4-8-15)14-31-23-25-17-11-12-30-20(17)21(29)27(23)16-9-5-2-6-10-16/h1-10,13H,11-12,14H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 55n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428029
PNG
(CHEMBL1257063)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(OC)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C26H21N5O5S/c1-35-16-9-7-15(8-10-16)31-25(34)19-6-4-3-5-18(19)23(30-31)24(33)27-14-22(32)29-26-28-20-12-11-17(36-2)13-21(20)37-26/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 60n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428057
PNG
(CHEMBL2324276)
Show SMILES COc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4OC)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C26H21N5O5S/c1-35-15-11-12-18-21(13-15)37-26(28-18)29-22(32)14-27-24(33)23-16-7-3-4-8-17(16)25(34)31(30-23)19-9-5-6-10-20(19)36-2/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 90n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428058
PNG
(CHEMBL2322631)
Show SMILES COc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccc(F)cc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H18FN5O4S/c1-35-16-10-11-19-20(12-16)36-25(28-19)29-21(32)13-27-23(33)22-17-4-2-3-5-18(17)24(34)31(30-22)15-8-6-14(26)7-9-15/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 90n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428036
PNG
(CHEMBL2324265)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)c2ccccc2c1=O
Show InChI InChI=1S/C25H15F4N5O3S/c26-14-6-8-15(9-7-14)34-23(37)17-4-2-1-3-16(17)21(33-34)22(36)30-12-20(35)32-24-31-18-10-5-13(25(27,28)29)11-19(18)38-24/h1-11H,12H2,(H,30,36)(H,31,32,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 90n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428032
PNG
(CHEMBL2325506)
Show SMILES COc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C23H17F3N4O3S3/c1-33-14-5-3-13(4-6-14)30-20(32)19-16(8-9-34-19)28-22(30)35-11-18(31)29-21-27-15-7-2-12(23(24,25)26)10-17(15)36-21/h2-7,10H,8-9,11H2,1H3,(H,27,29,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 100n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428034
PNG
(CHEMBL2324267)
Show SMILES Fc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C22H14F4N4O2S3/c23-12-2-4-13(5-3-12)30-19(32)18-15(7-8-33-18)28-21(30)34-10-17(31)29-20-27-14-6-1-11(22(24,25)26)9-16(14)35-20/h1-6,9H,7-8,10H2,(H,27,29,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 100n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428051
PNG
(CHEMBL2322621)
Show SMILES Cc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccc(F)cc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H18FN5O3S/c1-14-6-11-19-20(12-14)35-25(28-19)29-21(32)13-27-23(33)22-17-4-2-3-5-18(17)24(34)31(30-22)16-9-7-15(26)8-10-16/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 100n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428037
PNG
(CHEMBL2325513)
Show SMILES FC(F)(F)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H16F3N5O3S/c26-25(27,28)14-10-11-18-19(12-14)37-24(30-18)31-20(34)13-29-22(35)21-16-8-4-5-9-17(16)23(36)33(32-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,29,35)(H,30,31,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 110n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428053
PNG
(CHEMBL2322619)
Show SMILES COc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(OC)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C23H20N4O4S3/c1-30-14-5-3-13(4-6-14)27-21(29)20-17(9-10-32-20)25-23(27)33-12-19(28)26-22-24-16-8-7-15(31-2)11-18(16)34-22/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 120n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428040
PNG
(CHEMBL2325510)
Show SMILES Fc1ccc(cc1)-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C21H14ClFN4O2S3/c22-11-1-6-14-16(9-11)32-20(24-14)26-17(28)10-31-21-25-15-7-8-30-18(15)19(29)27(21)13-4-2-12(23)3-5-13/h1-6,9H,7-8,10H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 175n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50427998
PNG
(CHEMBL2322630)
Show SMILES COc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C25H19N5O4S/c1-34-16-11-12-19-20(13-16)35-25(27-19)28-21(31)14-26-23(32)22-17-9-5-6-10-18(17)24(33)30(29-22)15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 210n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428031
PNG
(CHEMBL2325507)
Show SMILES [O-][N+](=O)c1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16N6O5S/c31-20(27-24-26-18-11-10-15(30(34)35)12-19(18)36-24)13-25-22(32)21-16-8-4-5-9-17(16)23(33)29(28-21)14-6-2-1-3-7-14/h1-12H,13H2,(H,25,32)(H,26,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 240n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428055
PNG
(CHEMBL2324278)
Show SMILES COc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1
Show InChI InChI=1S/C22H17FN4O3S3/c1-30-14-6-7-15-17(10-14)33-21(24-15)26-18(28)11-32-22-25-16-8-9-31-19(16)20(29)27(22)13-4-2-12(23)3-5-13/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 250n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428025
PNG
(CHEMBL2323234)
Show SMILES CCOC(=O)c1ccc(NC(=O)CSc2nc3CCSc3c(=O)n2-c2ccccc2)cc1
Show InChI InChI=1S/C23H21N3O4S2/c1-2-30-22(29)15-8-10-16(11-9-15)24-19(27)14-32-23-25-18-12-13-31-20(18)21(28)26(23)17-6-4-3-5-7-17/h3-11H,2,12-14H2,1H3,(H,24,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428021
PNG
(CHEMBL2323238)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C23H18N4O2S3/c28-19(26-22-24-18(13-31-22)15-7-3-1-4-8-15)14-32-23-25-17-11-12-30-20(17)21(29)27(23)16-9-5-2-6-10-16/h1-10,13H,11-12,14H2,(H,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 350n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428045
PNG
(CHEMBL2324272)
Show SMILES Fc1ccc2nc(NC(=O)CNC(=O)c3nn(-c4ccccc4)c(=O)c4ccccc34)sc2c1
Show InChI InChI=1S/C24H16FN5O3S/c25-14-10-11-18-19(12-14)34-24(27-18)28-20(31)13-26-22(32)21-16-8-4-5-9-17(16)23(33)30(29-21)15-6-2-1-3-7-15/h1-12H,13H2,(H,26,32)(H,27,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 470n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428022
PNG
(CHEMBL2323237)
Show SMILES COc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)ccc2c1
Show InChI InChI=1S/C24H20N4O3S2/c1-31-17-8-9-18-15(13-17)7-10-20(25-18)27-21(29)14-33-24-26-19-11-12-32-22(19)23(30)28(24)16-5-3-2-4-6-16/h2-10,13H,11-12,14H2,1H3,(H,25,27,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 580n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 63 total )  |  Next  |  Last  >>
Jump to: