BDBM317030 N-[2,4-Difluoro-3-(4- isopropylamino-7H- pyrrolo[2,3-d]pyrimidine-5- carbonyl)-phenyl]-2-fluoro- benzenesulfonamide::US9617267, Compound P-1073

SMILES CC(C)Nc1ncnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)c12

InChI Key InChIKey=KUEKDIBEMNSMDR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 317030   

TargetCytochrome P450 2C19(Human)
Plexxikon

US Patent
LigandPNGBDBM317030(US9617267, Compound P-1073 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Plexxikon

US Patent
LigandPNGBDBM317030(US9617267, Compound P-1073 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Plexxikon

US Patent
LigandPNGBDBM317030(US9617267, Compound P-1073 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Plexxikon

US Patent
LigandPNGBDBM317030(US9617267, Compound P-1073 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM317030(US9617267, Compound P-1073 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM317030(US9617267, Compound P-1073 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent