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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science 382: (2023)
Cornell University
Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation.
ACS Med Chem Lett 14: 841-845 (2023)
Novartis Institutes For Biomedical Research
Novel Aryl Hydrocarbon Receptor Agonists for Treating Psoriasis.
ACS Med Chem Lett 14: 696-697 (2023)
Smith, Gambrell & Russell
Covalent
ACS Med Chem Lett 14: 777-787 (2023)
Johannes Gutenberg University Mainz
Design, Synthesis, and Structure-Activity Relationships of Biaryl Anilines as Subtype-Selective PPAR-alpha Agonists.
ACS Med Chem Lett 14: 766-776 (2023)
University of Minnesota
-Aryl Indoles as a Novel Class of Potent Na
ACS Med Chem Lett 14: 788-793 (2023)
Daiichi Sankyo
Discovery of Selective and Potent KRAS
ACS Med Chem Lett 14: 689-691 (2023)
Usona Institute
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors.
ACS Med Chem Lett 14: 810-819 (2023)
Jamia Millia Islamia
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.
ACS Med Chem Lett 14: 833-840 (2023)
Johann Wolfgang Goethe-University
TMPRSS2 Inhibitor Discovery Facilitated through an
ACS Med Chem Lett 14: 860-866 (2023)
University of Michigan
CitA activity is modulated by cysteine oxidation and pyruvate binding.
RSC Med Chem 14: 921-933 (2023)
University of Nebraska
Insights into targeting SARS-CoV-2: design, synthesis,
RSC Med Chem 14: 899-920 (2023)
Egyptian Russian University
Identification of ARUK2002821 as an isoform-selective PI5P4K? inhibitor.
RSC Med Chem 14: 934-946 (2023)
University of Cambridge
Improving binding entropy by higher ligand symmetry? - A case study with human matriptase.
RSC Med Chem 14: 969-982 (2023)
Johannes Gutenberg-University Staudingerweg
Investigating the interactions of flavonoids with human OATP2B1: inhibition assay, IC
RSC Med Chem 14: 890-898 (2023)
Soochow University
Synthesis and structure-activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein.
RSC Med Chem 14: 858-868 (2023)
University of Wollongong
Oxazolidinones as versatile scaffolds in medicinal chemistry.
RSC Med Chem 14: 823-847 (2023)
University College London
Design, synthesis and biological evaluation of novel indole-3-carboxylic acid derivatives with antihypertensive activity.
Bioorg Med Chem Lett 90: (2023)
Lomonosov Moscow State University
Design, synthesis, and pharmacological evaluation of N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potential for cytochrome P450 1A2 induction.
Bioorg Med Chem 87: (2023)
Astellas Pharma
Novel AHR Agonists for Treating Psoriasis.
ACS Med Chem Lett 14: 543-544 (2023)
Smith, Gambrell & Russell
Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors.
ACS Med Chem Lett 14: 606-613 (2023)
Northwestern University
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines.
ACS Med Chem Lett 14: 591-598 (2023)
Tu Dortmund University
Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders.
ACS Med Chem Lett 14: 545-546 (2023)
Smith, Gambrell & Russell
1,2,4-Triazine Derivatives as NLRP3 Inhibitors for Treating Diseases.
ACS Med Chem Lett 14: 547-548 (2023)
Smith, Gambrell & Russell
Novel Serine-Arginine Protein Kinase Inhibitors for Treating Cancer.
ACS Med Chem Lett 14: 551-552 (2023)
Smith, Gambrell & Russell
PROTAC: Harnessing Targeted Chimeras for Selective BCL-2 Degradation in Cancer Treatment.
ACS Med Chem Lett 14: 541-542 (2023)
Usona Institute
Synthesis of Veliparib Prodrugs and Determination of Drug-Release-Dependent PARP-1 Inhibition.
ACS Med Chem Lett 14: 652-657 (2023)
University of Pittsburgh
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol.
ACS Med Chem Lett 14: 614-620 (2023)
University of North Carolina at Chapel Hill
Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues.
ACS Med Chem Lett 14: 621-628 (2023)
University of Cambridge
Selective Wee1 Inhibitors Led to Antitumor Activity
ACS Med Chem Lett 14: 566-576 (2023)
Emd Serono
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions.
ACS Med Chem Lett 14: 549-550 (2023)
Smith, Gambrell & Russell
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett 14: 645-651 (2023)
IRBM
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
ACS Med Chem Lett 14: 658-665 (2023)
Japan Tobacco
Design, synthesis, and anticancer evaluation of arylurea derivatives as potent and selective type II irreversible covalent FGFR4 inhibitors.
Bioorg Med Chem 87: (2023)
China Pharmaceutical University
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg Med Chem Lett 90: (2023)
Infex Therapeutics
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety.
Bioorg Med Chem 87: (2023)
An Hui University of Traditional Chinese Medicine
Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway.
Bioorg Med Chem Lett 90: (2023)
Korea Institute of Science and Technology
The lipidation and glycosylation enabling bioactivity enhancement and structural change of antibacterial peptide G3.
Bioorg Med Chem Lett 90: (2023)
Fujian Normal University
Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors.
Bioorg Med Chem 87: (2023)
Zhejiang University
Design, synthesis and biological evaluation of novel indole-piperazine derivatives as antibacterial agents.
Bioorg Med Chem Lett 89: (2023)
Northwest A&F University
Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET.
Bioorg Med Chem Lett 89: (2023)
West Virginia University
Design, synthesis, and biological evaluation of acyl sulfonamide derivatives with spiro cycles as Na
Bioorg Med Chem 86: (2023)
Fudan University
Synthesis of novel ciprofloxacin-avibactam conjugates for the development of second-generation non-?-lactam-?-lactamase inhibitors.
Bioorg Med Chem Lett 88: (2023)
CSIR-Institute of Himalayan Bioresource Technology
Discovery of imidazo[1,2-b]pyridazine macrocyclic derivatives as novel ALK inhibitors capable of combating multiple resistant mutants.
Bioorg Med Chem Lett 89: (2023)
Shanghai Institute of Pharmaceutical Industry Co.
Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K? inhibitors via virtual screening and docking-based structure optimization.
Bioorg Med Chem 86: (2023)
Zhejiang University
Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.
RSC Med Chem 14: 734-744 (2023)
Jouf University Al-Qurayyat
Development of thiazole-appended novel hydrazones as a new class of ?-amylase inhibitors with anticancer assets: an
RSC Med Chem 14: 757-781 (2023)
Ccs Haryana Agricultural University
Ribosome-targeting antibiotics and resistance
RSC Med Chem 14: 624-643 (2023)
Emory University
Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint.
RSC Med Chem 14: 658-670 (2023)
Kansas State University
Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity.
RSC Med Chem 14: 782-789 (2023)
Virginia Tech
Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.
Bioorg Med Chem Lett 88: (2023)
Bristol Myers Squibb
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Med Chem Lett 89: (2023)
Pusan National University
Design, synthesis, and biological evaluation of novel HDAC inhibitors with a 3-(benzazol-2-yl)quinoxaline framework.
Bioorg Med Chem Lett 88: (2023)
Southeast University
Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening.
Bioorg Med Chem Lett 88: (2023)
Queens College of the City University of New York
Identification of small molecule inhibitors against MMP-14 via High-Throughput screening.
Bioorg Med Chem 85: (2023)
University of Illinois at Chicago
Enzymatic transformation of esculetin as a potent class of ?-glucosidase inhibitors.
Bioorg Med Chem Lett 88: (2023)
Korea Atomic Energy Research Institute (KAERI)
Synthesis and evaluation of sulfonamide derivatives targeting EGFR
Bioorg Med Chem 85: (2023)
Shenyang Pharmaceutical University
Design, synthesis and bioactivity evaluations of 8-substituted-quinoline-2-carboxamide derivatives as novel histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem 85: (2023)
Shandong University
Targeting the "Undruggable" Driver Protein, KRAS
ACS Med Chem Lett 14: 365-366 (2023)
Usona Institute
Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors.
ACS Med Chem Lett 14: 417-424 (2023)
University of Siena
The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders.
ACS Med Chem Lett 14: 499-505 (2023)
Sosei Heptares
Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35.
ACS Med Chem Lett 14: 411-416 (2023)
Dalian Institute of Chemical Physics
Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands.
ACS Med Chem Lett 14: 479-486 (2023)
Hun Biological Research Centre, Szeged
Prenylated Chrysin Derivatives as Partial PPAR? Agonists with Adiponectin Secretion-Inducing Activity.
ACS Med Chem Lett 14: 425-431 (2023)
Seoul National University
Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use.
ACS Med Chem Lett 14: 396-404 (2023)
Taiho Pharmaceutical
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.
ACS Med Chem Lett 14: 432-441 (2023)
University of North Carolina At Chapel Hill
Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry.
ACS Med Chem Lett 14: 458-465 (2023)
University of Gdansk
Accelerating Drug Discovery: Synthesis of Complex Chemotypes via Multicomponent Reactions.
ACS Med Chem Lett 14: 376-385 (2023)
Atavistik Bio
Discovery of Potent Deuterated Compounds as Potential KRAS
ACS Med Chem Lett 14: 362-364 (2023)
Usona Institute
Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.
ACS Med Chem Lett 14: 350-361 (2023)
The Baruch S. Blumberg Institute
Synthesis and biological evaluation of novel pteridin-7(8H)-one derivatives as potent CDK2 inhibitors.
Bioorg Med Chem Lett 88: (2023)
Jiangnan University
Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase.
Bioorg Med Chem Lett 88: (2023)
University of California at San Francisco
3-Arylidene-2-oxindoles as GSK3? inhibitors and anti-thrombotic agents.
Bioorg Med Chem Lett 87: (2023)
Volgograd State Medical University
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Bioorg Med Chem Lett 88: (2023)
Bristol Myers Squibb
Hydrazinecarbonyl-thiazol-2-acetamides with pronounced apoptotic behavior: synthesis, in vitro/in vivo anti-proliferative activity and molecular modeling simulations.
Bioorg Med Chem Lett 87: (2023)
Mansoura University
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Bioorg Med Chem 85: (2023)
University of Alberta
Siderophores: Chemical tools for precise antibiotic delivery.
Bioorg Med Chem Lett 87: (2023)
Universidade De Santiago De Compostela
Identification of a Noxo1 inhibitor by addition of a polyethylene glycol chain.
Bioorg Med Chem 85: (2023)
University of Cincinnati
Bacterial GTPases as druggable targets to tackle antimicrobial resistance.
Bioorg Med Chem Lett 87: (2023)
Indian Institute of Science Education and Research Bhopal
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Bioorg Med Chem 85: (2023)
Bristol Myers Squibb
Discovery of FXR/PPAR? dual partial agonist.
Bioorg Med Chem 85: (2023)
Hiroshima International University
An ATG4B inhibitor blocks autophagy and sensitizes Sorafenib inhibition activities in HCC tumor cells.
Bioorg Med Chem 84: (2023)
Yantai University
Design, synthesis and biological evaluation of quinazoline SOS1 inhibitors.
Bioorg Med Chem Lett 88: (2023)
Jiangnan University
Design, synthesis and bioactivity evaluation of a series of quinazolinone derivatives as potent PI3K? antagonist.
Bioorg Med Chem 84: (2023)
Southern Medical University
Palbociclib and Michael-acceptor hybrid compounds as CDK4/6 covalent inhibitors: Improved potency, broad anticancer spectrum and overcoming drug resistance.
Bioorg Med Chem 84: (2023)
Southeast University
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT
Bioorg Med Chem 84: (2023)
University of Sassari
Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist.
Bioorg Med Chem 84: (2023)
Byondis
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