The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.3M data for 1.0M Compounds and 8.6K Targets. Of those, 990K data for 465K Compounds and 4.2K Targets were curated by BindingDB curators.

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Recently Added Targets

    1. UDP-3-O-acyl-N-acetylglucosamine deacetylase, Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578), A6T4N9 (Curated 07/25/21), lpxC: 3 subμM ligands
    2. Sodium channel subunit beta-2, Human, O60939 (Curated 08/13/21), SCN2B: 17 subμM ligands
    3. Ataxin-2, Mouse, O70305 (Curated 08/12/21), Atxn2: 6 subμM ligands
    4. Protein phosphatase 1 regulatory subunit 15A, Human, O75807 (Curated 08/14/21), PPP1R15A: 1 subμM ligands
    5. DNA (cytosine-5)-methyltransferase 3A, Mouse, O88508 (Curated 08/13/21), Dnmt3a: 1 subμM ligands
    6. Complement factor B, Mouse, P04186 (Curated 08/12/21), Cfb: 6 subμM ligands
    7. Thrombospondin-1, Human, P07996 (Curated 08/13/21), THBS1: 14 subμM ligands
    8. S-formylglutathione hydrolase, Human, P10768 (Curated 08/13/21), ESD: 1 subμM ligands
    9. Beta-glucuronidase, Mouse, P12265 (Curated 08/12/21), Gusb: 1 subμM ligands
    10. Diacylglycerol kinase alpha, Human, P23743 (Curated 08/13/21), DGKA: 4 subμM ligands
    11. Carbamoyl-phosphate synthase [ammonia], mitochondrial, Human, P31327 (Curated 08/13/21), CPS1: 7 subμM ligands
    12. Stress-70 protein, mitochondrial, Human, P38646 (Curated 08/12/21), HSPA9: 5 subμM ligands
    13. Phospholipase A and acyltransferase 3, Human, P53816 (Curated 08/13/21), PLAAT3: 16 subμM ligands
    14. Sodium channel subunit beta-1, Mouse, P97952 (Curated 08/13/21), Scn1b: 1 subμM ligands
    15. Programmed cell death protein 1, Mouse, Q02242 (Curated 08/13/21), Pdcd1: 1 subμM ligands
    16. TAR DNA-binding protein 43, Human, Q13148 (Curated 08/14/21), TARDBP: 2 subμM ligands
    17. Collagenase ColH, Hathewaya histolytica, Q46085 (Curated 08/13/21), colH: 3 subμM ligands
    18. Sodium channel subunit beta-2, Mouse, Q56A07 (Curated 08/13/21), Scn2b: 13 subμM ligands
    19. Protein phosphatase 1 regulatory subunit 15B, Human, Q5SWA1 (Curated 08/14/21), PPP1R15B: 1 subμM ligands
    20. Sodium channel protein type 9 subunit alpha, Mouse, Q62205 (Curated 12/17/16), Scn9a: 52 subμM ligands
    21. BTB/POZ domain-containing protein KCTD11, Human, Q693B1 (Curated 08/12/21), KCTD11: 1 subμM ligands
    22. Fatty acid 2-hydroxylase, Human, Q7L5A8 (Curated 09/06/21), FA2H: 57 subμM ligands
    23. Structural polyprotein, CHIKV, Q8JUX5 (Curated 07/25/21), : 3 subμM ligands
    24. Interleukin-1 receptor-associated kinase 4, Mouse, Q8R4K2 (Curated 08/13/21), Irak4: 1 subμM ligands
    25. Phospholipase A and acyltransferase 5, Human, Q96KN8 (Curated 08/13/21), PLAAT5: 28 subμM ligands
    26. Serine/threonine-protein kinase LMTK3, Human, Q96Q04 (Curated 08/13/21), LMTK3: 6 subμM ligands
    27. TSC22 domain family protein 3, Human, Q99576 (Curated 07/25/21), TSC22D3: 21 subμM ligands
    28. Programmed cell death 1 ligand 2, Human, Q9BQ51 (Curated 08/15/21), PDCD1LG2: 313 subμM ligands
    29. Programmed cell death 1 ligand 1, Mouse, Q9EP73 (Curated 08/13/21), Cd274: 2 subμM ligands
    30. Toll-like receptor 9, Mouse, Q9EQU3 (Curated 08/13/21), Tlr9: 1 subμM ligands
    31. N-alpha-acetyltransferase 50, Human, Q9GZZ1 (Curated 08/13/21), NAA50: 12 subμM ligands
    32. OXA23 carbapenemase, Acinetobacter baumannii, Q9L4P2 (Curated 08/13/21), ari-1: 1 subμM ligands
    33. Phospholipase A and acyltransferase 2, Human, Q9NWW9 (Curated 08/13/21), PLAAT2: 10 subμM ligands
    34. Phospholipase A and acyltransferase 4, Human, Q9UL19 (Curated 08/13/21), PLAAT4: 10 subμM ligands

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BindingDB Data Curation

BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of September 18, 2021, BindingDB's patent dataset comprises:

  1. Patents: 5,025
  2. Binding measurements: 748,866
  3. Compounds: 375,047
  4. Target proteins: 2,118
  5. Assays: 7,278
  6. Average Number of Targets per Patent: 1.92

BindingDB curates a set of journals not covered by other public databases. As of September 18, 2021, the status of this curation effort is as follows:

BindingDB is supported by NIH's National Institute of General Medical Sciences (GM070064), and is located at the Skaggs School of Pharmacy and Pharmaceutical Sciences of the University of California San Diego