BDBM385997 (S)-6-(4-(4-fluorophenyl)-1-(1-hydroxybutan-2-yl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile::US10287295, Example 6'::US11352360, Example 6'

SMILES CC[C@H](CO)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=QYXUDJJTDANZPN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 385997   

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM385997((S)-6-(4-(4-fluorophenyl)-1-(1-hydroxybutan-2-yl)-...)
Affinity DataIC50: 5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Syngene International

US Patent
LigandPNGBDBM385997((S)-6-(4-(4-fluorophenyl)-1-(1-hydroxybutan-2-yl)-...)
Affinity DataIC50: 5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM385997((S)-6-(4-(4-fluorophenyl)-1-(1-hydroxybutan-2-yl)-...)
Affinity DataIC50: 1.02E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM385997((S)-6-(4-(4-fluorophenyl)-1-(1-hydroxybutan-2-yl)-...)
Affinity DataIC50: 1.02E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent