BDBM50131049 11-Methoxy-8,13-dihydro-7H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5-one::CHEMBL312149

SMILES COc1ccc2c3CCn4c(nc5ccccc5c4=O)-c3[nH]c2c1

InChI Key InChIKey=POMASUJAYQAJQZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50131049   

TargetCytochrome P450 1B1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50131049(11-Methoxy-8,13-dihydro-7H-indolo[2',3':3,4]pyrido...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1B1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50131049(11-Methoxy-8,13-dihydro-7H-indolo[2',3':3,4]pyrido...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Cytochrome P450 1B1 expressed in bacterial membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
National Research Institute of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50131049(11-Methoxy-8,13-dihydro-7H-indolo[2',3':3,4]pyrido...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of Cytochrome P450 1A2 enzyme in bacterial membrane expressing human P450sMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A1(Human)
National Research Institute of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50131049(11-Methoxy-8,13-dihydro-7H-indolo[2',3':3,4]pyrido...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Cytochrome P450 1A1 enzyme in bacterial membrane expressing human P450sMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Changzhou University

Curated by ChEMBL
LigandPNGBDBM50131049(11-Methoxy-8,13-dihydro-7H-indolo[2',3':3,4]pyrido...)
Affinity DataIC50: 2.21E+4nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed