BDBM50320968 2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic acid(2-methyl-2H-pyrazol-3-ylmethyl)-amide::CHEMBL1164262

SMILES Cn1nccc1CNC(=O)c1ccc2cc([nH]c2c1)-c1n[nH]cc1-c1ccccc1

InChI Key InChIKey=ZBWNGWQIOSOFMY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50320968   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320968(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged full length CDK2/Cyclin E after 40 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320968(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 630nMAssay Description:Inhibition of GST-tagged full length recombinant ITK after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320968(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of GST-tagged full length GSK3-beta assessed as inhibition of ATP consumption after 60 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320968(2-(4-Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxyli...)
Affinity DataIC50: 9.33E+3nMAssay Description:Inhibition of GST-tagged recombinant INSR catalytic domain expressed in baculovirus-infected Sf21 cells after 80 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed